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Neuroleptic malignant syndrome and subsequent clozapine-withdrawal effects in a patient with refractory schizophrenia
Minfeng Cheng1, Huaying Gu1, Liangrong Zheng1
1Department of Psychiatry, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Abstract:
Here, we report a female patient developing neuroleptic malignant syndrome following the use of a combination of clozapine and haloperidol. Subsequently, the patient presented withdrawal effects after an abrupt discontinuation of clozapine. Psychiatrists not aware of possible clozapine-withdrawal effects may misdiagnose as a part of the primary mental illness or as the initial symptoms worsening, if unrecognized.
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