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Updated: Mar 22, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Post dengue neurological complication.

A H Hasliza¹, H Tohid², K Y Loh³

¹Hasliza Abu Hassan MMed (Family Medicine) (UKM) Department of Primary Care Medicine, Faculty of Medicine and Defense Health, National Defense, 57000 Kuala Lumpur, Malaysia.

Malaysian Family Physician : the Official Journal of the Academy of Family Physicians of Malaysia

|April 22, 2016

Summary

This summary is machine-generated.

Dengue infection can cause rare neurological complications like Guillain-Barré syndrome (GBS). A case study highlights thrombocytopenia as a key indicator in patients without typical dengue fever symptoms.

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Area of Science:

Neurology
Infectious Diseases
Public Health

Background:

Dengue fever is endemic in tropical regions, including Malaysia.
Neurological complications from dengue are infrequent but significant.
Guillain-Barré syndrome (GBS) is a rare neurological complication associated with viral infections.

Observation:

A 39-year-old woman presented with neurological symptoms suggestive of GBS.
The patient lacked typical dengue fever signs and symptoms.
She had a recent history of acute gastroenteritis (AGE) and upper respiratory tract infection (URTI).

Findings:

GBS was diagnosed, likely secondary to post-viral AGE and URTI.
Thrombocytopenia was the sole laboratory finding indicating a possible dengue infection.
This case underscores the diagnostic challenge of dengue-associated GBS without classic dengue presentation.

Implications:

Highlights the importance of considering dengue in GBS cases, even with atypical presentations.
Suggests that thrombocytopenia may be a crucial diagnostic clue for dengue in such scenarios.
Emphasizes the need for heightened clinical suspicion and diagnostic vigilance for dengue's neurological sequelae in endemic areas.