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Seizures associated with Lupus during pregnancy
Shigeru Aoki1, Natsuko Kobayashi1, Aya Mochimaru1
1Perinatal Center for Maternity and Neonate Yokohama City University Medical Center Yokohama Japan.
Clinical Case Reports
|April 22, 2016
Summary
Systemic lupus erythematosus (SLE) flares can cause central nervous system (CNS) lupus. During pregnancy, seizures from CNS lupus may lead to infant hypoxic-ischemic encephalopathy (HIE).
Area of Science:
- Neurology
- Rheumatology
- Obstetrics
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- SLE can affect various organ systems, including the central nervous system (CNS).
- Pregnancy can alter SLE disease activity.
Observation:
- Sudden flares of previously stable SLE can manifest as CNS lupus.
- Seizures are a potential neurological complication of CNS lupus.
- These seizures can occur during pregnancy.
Findings:
- CNS lupus during pregnancy poses a risk to the fetus.
- Seizures associated with maternal CNS lupus can induce hypoxic-ischemic encephalopathy (HIE) in the infant.
- HIE is a serious neonatal condition resulting from oxygen deprivation.
Implications:
- Early recognition and management of SLE flares in pregnant individuals are crucial.
- Close monitoring for neurological symptoms in pregnant SLE patients is essential.
- Preventing maternal seizures may mitigate the risk of neonatal HIE, improving infant outcomes.
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