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Related Experiment Video

Updated: Mar 22, 2026

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Published on: March 30, 2016

Inhibition Patterns the Whisking Rhythm.

Varun Sreenivasan¹, Carl C H Petersen¹

¹Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland.

|April 22, 2016

Summary

This summary is machine-generated.

Rhythmic inhibition of whisker motor neurons, driven by brainstem oscillators synchronized with breathing, generates exploratory whisking movements. This discovery highlights a key neural pattern generator for sensory exploration.

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Last Updated: Mar 22, 2026

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

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Juxtacellular Monitoring and Localization of Single Neurons within Sub-cortical Brain Structures of Alert, Head-restrained Rats

Juxtacellular Monitoring and Localization of Single Neurons within Sub-cortical Brain Structures of Alert, Head-restrained Rats

Published on: April 27, 2015

Area of Science:

Neuroscience
Motor Control
Sensory Systems

Background:

Exploratory whisking is crucial for tactile sensory information gathering in rodents.
The neural circuits controlling whisking are not fully understood.
Rhythmic motor patterns often arise from central pattern generators.

Purpose of the Study:

To identify the neural mechanisms underlying the rhythmic generation of exploratory whisking.
To investigate the role of inhibitory premotor neurons in whisking control.
To determine the influence of respiratory rhythms on whisking patterns.

Main Methods:

Electrophysiological recordings in brainstem slices.
In vivo electrophysiology to record from whisker motor neurons.
Analysis of neural activity synchronized with breathing and whisking.

Main Results:

Identified synchronized rhythmic inhibition of whisker motor neurons.
Demonstrated that inhibitory premotor neurons in the brainstem reticular formation are involved.
Showed that these premotor neurons are synchronized by breathing-related oscillators.

Conclusions:

Rhythmic inhibition of whisker motor neurons acts as a key pattern generator for exploratory whisking.
Breathing-related oscillators in the brainstem synchronize inhibitory premotor neurons to produce whisking rhythms.
This provides a novel insight into the neural basis of sensory-driven motor behaviors.