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Neonatal Outcome in Pregnancies with Autoimmune Myasthenia Gravis
Miljana Z Jovandaric1, Dina J Despotovic1, Milos M Jesic2
1a Department of Neonatology , Clinic for Gynecology and Obstetrics, Clinical Center of Serbia , Belgrade , Serbia.
Introduction:
Acquired autoimmune myasthenia gravis (MG) is an autoimmune process in which antibodies (AB) directed against the acetylcholine nicotinic receptor (AChR) cause weakness and fatigue of striated muscles.
Objectives:
The objective of this study was to determine the range of clinical manifestations in newborns with transient neonatal myasthenia (TNM).
Methods:
62 newborns with mothers who had autoimmune MG were followed by: anthropometric parameters, gestational age, gender, type of delivery completion, Apgar score (AS) in the first and fifth minute, and the emergence of TNM symptoms.
Results:
For fourteen consecutive years, from a total of 98,000 infants, 62 (0.06%) were born to mothers with autoimmune MG. Four of them (6.4%) had symptoms of TNM.
Conclusion:
Newborns of mothers with MG manifest clinical features of TNM relative to stage of mother's illness. These newborns need monitoring until the seventh day of life.
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