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The role of annexin A4 in cancer

Houshan Yao1, Chang Sun1, Zhiqian Hu1

  • 1Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China.

Frontiers in Bioscience (Landmark Edition)
|April 22, 2016
PubMed

Insights

Annexin A4 (ANXA4) is linked to tumor development and invasion across many cancers. Reducing ANXA4 may improve chemotherapy effectiveness and offers a potential therapeutic target for cancer treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Annexin A4 (ANXA4) is a calcium and phospholipid-binding protein.
  • ANXA4 plays roles in membrane dynamics, cell growth, apoptosis, and tumor progression.

Purpose of the Study:

  • To investigate the role of ANXA4 in various epithelial cancers.
  • To evaluate ANXA4 as a potential biomarker and therapeutic target.

Main Methods:

  • Analysis of ANXA4 expression in clinical epithelial tumors.
  • Investigating the effects of ANXA4 knockdown on cancer cell migration and drug resistance.

Main Results:

  • ANXA4 overexpression is found in lung, gastric, colorectal, pancreatic, breast, ovarian, and other cancers.
  • ANXA4 knockdown reduced migration in ovarian and breast cancer cells.
  • ANXA4 knockdown increased sensitivity to platinum-based chemotherapy in ovarian cancer and mesothelioma cells.

Conclusions:

  • ANXA4 is implicated in tumor development, invasion, and chemoresistance.
  • ANXA4 may serve as a prognostic indicator and a therapeutic target for cancer patients.

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