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Updated: Mar 22, 2026

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Diazoxide accelerates wound healing by improving EPC function.

Zhang-Peng Li1, Ru-Juan Xin1, Hong Yang1

  • 1Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Frontiers in Bioscience (Landmark Edition)
|April 22, 2016
PubMed
Summary
This summary is machine-generated.

Diazoxide accelerates wound healing in diabetic mice by improving endothelial progenitor cell function. This effect is linked to the regulation of p53 and TSP-1 pathways, crucial for diabetic wound repair.

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Area of Science:

  • Biomedical research
  • Diabetes complications
  • Wound healing

Background:

  • Endothelial cell dysfunction is a primary cause of microvascular complications in diabetes.
  • Diabetes significantly impairs wound healing and endothelial progenitor cell (EPC) function.
  • Diazoxide is known to affect beta cells by opening ATP-sensitive K+ channels.

Purpose of the Study:

  • To investigate the role of diazoxide in promoting wound healing in a mouse model of diabetes.
  • To explore the underlying mechanisms by which diazoxide influences EPC function and wound repair.

Main Methods:

  • Streptozotocin (STZ)-induced diabetes model in mice.
  • Assessment of wound closure, angiogenesis, and circulating EPC levels.
  • In vitro analysis of bone marrow (BM)-EPC adhesion, migration, and tube formation.
  • Evaluation of p53 and TSP-1 expression in diabetic mice and BM-EPCs.

Main Results:

  • Diazoxide treatment accelerated wound closure and stimulated angiogenesis in diabetic mice.
  • Circulating EPCs and their functional capacities (adhesion, migration, tube formation) were improved by diazoxide.
  • Diazoxide inhibited the increased expression of p53 and TSP-1 in diabetic mice and high-glucose-treated BM-EPCs.

Conclusions:

  • Diazoxide enhances wound healing in diabetes by improving BM-EPC function.
  • The therapeutic effect of diazoxide may involve the p53 and TSP-1 signaling pathways.
  • Diazoxide shows potential as a therapeutic agent for diabetic wound complications.