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Clinical Characteristics of Stenotrophomonas maltophilia Keratitis

An-Lun Wu1, Lung-Kun Yeh, David H K Ma

  • 1*Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan; †College of Medicine, Chang Gung University, Taoyuan, Taiwan; and ‡Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.

Cornea
|April 22, 2016
PubMed
Abstract

Insights

Stenotrophomonas maltophilia keratitis is uncommon but affects those with compromised eyes. Fluoroquinolones like levofloxacin show effectiveness in treating this infection, with most patients responding well to topical antimicrobial treatment.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Stenotrophomonas maltophilia is an opportunistic pathogen.
  • It is an uncommon cause of infectious keratitis.

Purpose of the Study:

  • To report clinical features, antibiotic susceptibility, treatments, and visual outcomes of S. maltophilia keratitis.
  • To compare clinical features with previously reported cases.

Main Methods:

  • Retrospective review of 21 patients with culture-proven S. maltophilia keratitis (2003-2014).
  • Comparison with 17 previously reported cases.
  • Analysis of clinical features, risk factors, and treatment outcomes.

Main Results:

  • Common risk factors include preexisting corneal disease, prior surgery, and contact lens wear.
  • All S. maltophilia isolates were susceptible to levofloxacin and moxifloxacin.
  • 81% of patients responded favorably to topical antimicrobials; 47.6% required surgery.

Conclusions:

  • S. maltophilia keratitis predominantly impacts individuals with compromised ocular surfaces.
  • The pathogen exhibits in vitro susceptibility and clinical responsiveness to fluoroquinolones.

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