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Related Concept Videos

Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Pain01:20

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Anti-Nuclear Antibody Screening Using HEp-2 Cells
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Autoantibodies and pain.

John M Dawes1, Angela Vincent

  • 1Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.

Current Opinion in Supportive and Palliative Care
|April 22, 2016
PubMed
Summary

Autoantibodies targeting neural cells may cause chronic pain conditions. Immunotherapies show promise in treating pain by reducing these autoantibodies, suggesting a direct link between autoantibodies and pathological pain.

Area of Science:

  • Neuroscience
  • Immunology

Background:

  • Neurological conditions linked to autoantibodies targeting neural cells have emerged.
  • Neuroimmune interactions are recognized contributors to chronic pain.

Purpose of the Study:

  • To review the role of autoantibodies in pathological pain.
  • To highlight the potential of targeting autoantibodies for pain management.

Main Methods:

  • Review of recent clinical and preclinical studies.
  • Analysis of immunotherapy outcomes in patients with specific conditions.
  • Examination of animal models using patient-derived autoantibodies.

Main Results:

  • Immunotherapy (e.g., plasma exchange, IVIg) reduced pain scores in conditions like complex regional pain syndrome and neuromyelitis optica.

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  • Autoantibodies from patients with rheumatoid arthritis or complex regional pain syndrome induced pain phenotypes in animal models.
  • Therapeutic success in patients and animal models supports a direct role for autoantibodies in pain.

    • Conclusions:

    • Growing evidence suggests autoantibodies contribute to certain pain syndromes.
    • Targeting autoantibodies offers potential therapeutic advantages for chronic pain patients.
    • This research has broader implications for understanding and treating widespread chronic pain.