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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Mar 22, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Immunotherapy for lung cancer.

Antonius Steven1,2, Scott A Fisher1,2, Bruce W Robinson1,2

  • 1School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia.

Respirology (Carlton, Vic.)
|April 22, 2016
PubMed
Summary
This summary is machine-generated.

Lung cancer immunotherapy, including immune checkpoint blockade, shows promise. Personalized cancer vaccines targeting neoantigens may further improve treatment efficacy and patient outcomes.

Keywords:
antigenantineoplastic agentsimmunotherapylung Cancervaccine

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Lung cancer remains a leading cause of cancer-related mortality globally.
  • Previous attempts at lung cancer immunotherapy yielded limited success.
  • Recent advancements have revitalized interest in cancer immunotherapy.

Purpose of the Study:

  • To review the efficacy of immune checkpoint blockade therapies in lung cancer.
  • To explore the potential of cancer vaccines, particularly those utilizing neoantigens.
  • To understand the mechanisms underlying cancer immune recognition and eradication.

Main Methods:

  • Literature review of clinical trials and research on lung cancer immunotherapy.
  • Analysis of immune checkpoint blockade mechanisms and outcomes.
  • Evaluation of cancer vaccine strategies, including neoantigen identification.

Main Results:

  • Immune checkpoint blockade therapies have demonstrated efficacious and durable responses in clinical trials.
  • Neoantigen identification holds potential for improving cancer vaccine efficacy.
  • Understanding immune cell interactions is crucial for optimizing current and future immunotherapies.

Conclusions:

  • There is growing optimism for the future of lung cancer immunotherapy.
  • Personalized immunotherapy, potentially combining vaccines and checkpoint blockade, offers a promising avenue.
  • Further research into immune recognition pathways will enhance therapeutic strategies.