Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Processes of Self-Presentation

Processes of Self-Presentation

Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...

Crossing Over

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...

Crossing Over

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...

Crossing over

Crossing over

Cross-Sectional Research

Cross-Sectional Research

In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...

Cross-reactivity

Cross-reactivity

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy.

Nature communications·2026

Same author

A Novel Proteoglycan-4 Isoform Drives Skeletal Regeneration.

bioRxiv : the preprint server for biology·2025

Same author

The HCMV tegument protein UL88 degrades MyD88 and reduces innate immune activation.

Journal of virology·2025

Same author

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling.

iScience·2025

Same author

HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis.

Journal of virology·2025

Same author

γδ T Cells Mediate a Requisite Portion of a Wound Healing Response Triggered by Cutaneous Poxvirus Infection.

Viruses·2024

Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026

Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026

Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026

Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026

Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026

Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Published on: September 28, 2022

Defining cross presentation for a wider audience.

Christopher C Norbury¹

¹Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

Current Opinion in Immunology

|April 22, 2016

Summary

This summary is machine-generated.

Cross presentation is key for immune responses. This study explores various pathways for antigen transfer and their roles in generating CD8+ T cells, crucial for fighting infections and tumors.

More Related Videos

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Cross-Modal Multivariate Pattern Analysis

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

Related Experiment Videos

Last Updated: Mar 22, 2026

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Published on: September 28, 2022

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Cross-Modal Multivariate Pattern Analysis

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

Cross presentation is the process where cells present antigens not translated within them on MHC Class I molecules.
Classical pathways are well-studied, but diverse mechanisms of antigen transfer (protein, peptide, RNA, DNA, peptide-MHC-I complexes) exist.
The contribution of these varied pathways to immune responses remains largely uncharacterized.

Purpose of the Study:

To investigate the diverse pathways involved in cross presentation.
To determine the peptide repertoires generated by different cross presentation routes.
To understand the role of these pathways in generating protective CD8+ T cell responses.

Main Methods:

Analysis of antigen transfer mechanisms.
Peptide repertoire profiling.
Assessment of CD8+ T cell activation and function.

Main Results:

Identified multiple pathways for antigen transfer in cross presentation.
Characterized distinct peptide repertoires arising from different transfer routes.
Demonstrated varying contributions of these pathways to CD8+ T cell immunity.

Conclusions:

Cross presentation involves a complex network of antigen transfer pathways.
Understanding these diverse pathways is critical for developing effective immunotherapies.
Further research is needed to fully elucidate their roles in immunity and disease.