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Mur (MNS 10) screening with a novel loop-mediated isothermal amplification assay in Zhongshan, China
1CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
Background:
The distribution of the Mur blood group antigen is 5-7% in the south of China, and a much higher prevalence is observed in some areas of the region. Anti-Mur can cause hemolytic disease of the newborn and severe transfusion reactions.
Objectives:
Genetic testing is more ideal than conventional serological tests because antibodies for detection are usually not available.
Methods:
In this study, a novel loop-mediated isothermal amplification (LAMP) assay for the detection of Mur blood group antigen was established.
Results:
Fifteen of 275 (5·5%) samples were confirmed by LAMP as Mur antigen positive. All the Mur antigen-positive samples were GP.Mur subtype which was confirmed with sequencing.
Conclusion:
The LAMP method has identical results with conventional serology method but more suitable for large-scale screening.
