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Ganoderic Acid and Lucidenic Acid (Triterpenoid).

Chin-Lin Hsu1, Gow-Chin Yen2

  • 1School of Nutrition, Chung Shan Medical University, Taichung, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan.

The Enzymes
|April 23, 2016
PubMed
Summary

Ganoderma lucidum mushrooms contain ganoderic and lucidenic acids, which show potential for treating various human diseases due to their diverse biological activities.

Keywords:
Biological functionsGanoderic acidsGanoderma speciesLucidenic acidsPharmacokinetics

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Area of Science:

  • Mycology
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Ganoderma species, particularly Ganoderma lucidum, are functional mushrooms widely used in Asian countries.
  • Triterpenoids, including ganoderic acids and lucidenic acids, are key bioactive compounds isolated from Ganoderma species.
  • These triterpenoids possess a broad spectrum of investigated biological activities.

Purpose of the Study:

  • To provide a detailed overview of the sources and biosynthesis of ganoderic acids and lucidenic acids.
  • To comprehensively review the diverse biological functions of these compounds.
  • To discuss their pharmacokinetic properties and potential therapeutic applications against human diseases.

Main Methods:

  • Literature review focusing on Ganoderma species, triterpenoids, ganoderic acids, and lucidenic acids.
  • Synthesis of information regarding isolation, biosynthesis pathways, and characterized biological activities.
  • Analysis of existing data on pharmacokinetics and disease-fighting potential.

Main Results:

  • Ganoderma species are rich sources of ganoderic and lucidenic acids.
  • These compounds exhibit a wide range of biological activities, including antibacterial, antiviral, antitumor, anti-inflammatory, and hepatoprotective effects.
  • Specific functions such as cell cytotoxicity, apoptosis induction, cell cycle arrest, anti-invasion, autophagy, antiosteoclastogenesis, antiasthma, and antihepatitis B activity have been documented.

Conclusions:

  • Ganoderic acids and lucidenic acids possess significant therapeutic potential.
  • Their diverse biological functions highlight their promise in combating various human diseases.
  • Further research into their pharmacokinetics and clinical applications is warranted.