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Updated: Jul 17, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
Hypercalcaemia as a manifestation of malignant urothelial change in analgesic nephropathy
N D Derbyshire1, A W Asscher, P N Matthews
1Department of Renal Medicine and Urology, Royal Infirmary, Cardiff, UK.
Abstract:
We report two cases of patients with analgesic nephropathy presenting with the symptoms of hypercalcaemia, and who were found to have transitional cell carcinomas of the renal pelvis. On removal of the tumours, calcium levels fell to normal, indicating that a humoral factor produced by the tumour caused the hypercalcaemia. We suggest that hypercalcaemia in a patient with analgesic nephropathy may indicate a malignant change, and that serum calcium should be assessed when such patients are reviewed.
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