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Oxidative stress, microRNAs and cytosolic calcium homeostasis

Alessandra Magenta1, Elena Dellambra1, Roberta Ciarapica1

  • 1Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Laboratorio di Patologia Vascolare, Via dei Monti di Creta 104, Rome 00167, Italy.

Cell Calcium
|April 23, 2016
PubMed

Insights

Reactive oxygen species (ROS) impact cell calcium levels (Cai) and microRNA (miRNA) expression. This review explores how specific miRNAs link ROS, Cai, and cell function, particularly in skin aging and diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Dermatology

Background:

  • Reactive oxygen species (ROS) are known to increase cytosolic calcium ions (Cai).
  • MicroRNAs (miRNAs) are also modulated by ROS, but the interplay between ROS, miRNAs, and Cai is not well understood.
  • Specific miRNAs are implicated in cellular signaling pathways affected by oxidative stress.

Purpose of the Study:

  • To review the current understanding of the relationship between ROS, miRNAs, and Cai.
  • To categorize miRNAs based on their modulation by ROS and/or Cai, and their effects on cell signaling.
  • To examine the role of these miRNAs in skin physiology and pathology.

Main Methods:

  • Literature review focusing on miRNAs modulated by ROS and/or Cai.
  • Analysis of miRNA effects on cell signaling and function.
  • Examination of miRNA roles in skin aging, UV response, psoriasis, and atopic dermatitis.

Main Results:

  • Identified three groups of miRNAs: those modulated by both ROS and Cai (miR-181a, miR-205); those modulated by ROS with effects on Cai (miR-1, miR-21, miR-24, miR-25, miR-185, miR-214); and those modulating both ROS and Cai (miR-133, miR-145, miR-495).
  • These miRNAs influence cell signaling and function.
  • Several miRNAs play roles in skin conditions linked to oxidative stress.

Conclusions:

  • The link between oxidative stress, miRNAs, and Cai is a complex and emerging area of research.
  • Further investigation is needed to fully elucidate the role of Cai in miRNA expression and the impact of miRNAs on Cai-dependent signaling.
  • These miRNAs represent potential therapeutic targets for oxidative stress-related skin conditions.
Keywords:
AgingCalciumDiseasesReactive oxigen speciesSkinmicroRNAs

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