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En bloc resection for osteogenic sarcoma.

R C Marcove

    Canadian Journal of Surgery. Journal Canadien De Chirurgie
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    En bloc resection offers a limb-sparing alternative for osteogenic sarcoma. This approach, combined with chemotherapy, shows promising survival rates for young patients, potentially avoiding amputation.

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    Area of Science:

    • Orthopedic Oncology
    • Surgical Oncology
    • Medical Oncology

    Background:

    • Osteogenic sarcoma in young patients traditionally necessitates amputation.
    • Limb preservation without compromising cancer surgery principles is a significant clinical goal.
    • Radical amputation combined with chemotherapy is the current standard curative treatment.

    Purpose of the Study:

    • To evaluate en bloc resection plus intensive chemotherapy as an alternative to amputation for osteogenic sarcoma.
    • To assess the efficacy and outcomes of limb-sparing surgery for various osteogenic sarcoma locations.

    Main Methods:

    • A study of 43 patients with osteogenic sarcoma undergoing en bloc resection.
    • Tumor resection sites included distal femur, proximal tibia, shoulder girdle, and fibula.

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  • Patients received adjuvant chemotherapy and, in some cases, pulmonary resection.

    • Main Results:

    • Overall survival rate was 74% (32 out of 43 patients) after treatment.
    • 67% (20 out of 43 patients) showed no evidence of distant disease post-treatment.
    • Among 38 patients without initial metastases, 63% (24 out of 38) remained disease-free postoperatively.

    Conclusions:

    • En bloc resection combined with chemotherapy is a viable limb-sparing alternative to amputation for osteogenic sarcoma.
    • This approach demonstrates encouraging survival and disease control rates in young patients.
    • Further research can optimize treatment protocols for improved outcomes in osteogenic sarcoma management.