Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting 2-Substituted-4(1<i>H</i>)-Quinolones for Targeting the <i>Plasmodium falciparum</i> Cytochrome bc<sub>1</sub> Complex.

Journal of medicinal chemistry·2026
Same author

Redox-active multi-thianthrene cycloparaphenylenes: synthesis and supramolecular properties.

Chemical communications (Cambridge, England)·2026
Same author

Co-templating of polyoxoniobates and silicate/germanate trimer-rings in crystals and inorganic gels.

Chemical science·2026
Same author

Building block approach to technetium-substituted polyoxotungstates.

Chemical communications (Cambridge, England)·2026
Same author

Aromatic Interactions Select for Homodimeric Assembly in a Quadruply Hydrogen-Bonded DADA 1,2-Azaphosphinine Dimer.

Journal of the American Chemical Society·2026
Same author

Unleashing the Power of Potassium 2-Ethylhexanoate as a Mild and Soluble Base for Pd-Catalyzed C-N Cross-Coupling.

Journal of the American Chemical Society·2025

Related Experiment Video

Updated: Mar 22, 2026

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
09:12

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

10.0K

Synthesis of tetraphosphine macrocycles using copper(i) templates.

Bryan P Nell1, Charles D Swor1, E Adrian Henle1

  • 1Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA. dtyler@uoregon.edu.

Dalton Transactions (Cambridge, England : 2003)
|April 23, 2016
PubMed
Summary

Researchers explored two novel synthetic routes for tetradentate phosphine macrocycles, utilizing copper(I) as a template ion. These methods successfully synthesized macrocyclic phosphines, paving the way for new coordination chemistry applications.

More Related Videos

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

3.9K
Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
12:30

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

9.7K

Related Experiment Videos

Last Updated: Mar 22, 2026

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
09:12

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

10.0K
Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

3.9K
Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
12:30

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

9.7K

Area of Science:

  • Coordination Chemistry
  • Organic Synthesis
  • Macrocyclic Chemistry

Background:

  • The synthesis of phosphine macrocycles is an underdeveloped area lacking standardized synthetic methodologies.
  • Copper(I) ions serve as effective template ions for macrocycle synthesis due to their facile removal without ligand degradation.

Purpose of the Study:

  • To investigate two general synthetic routes for tetradentate phosphine macrocycles.
  • To explore the utility of copper(I) as a template ion in macrocyclic phosphine synthesis.
  • To synthesize and characterize novel tetradentate phosphine macrocycles.

Main Methods:

  • Investigated two distinct synthetic pathways for macrocycle formation.
  • Employed copper(I) as a template ion in both synthetic routes.
  • Utilized coupling reactions of bidentate phosphines and alkylation of open-chain phosphines.
  • Demonstrated demetallation using aqueous KCN to obtain free macrocyclic phosphines.

Main Results:

  • Successfully synthesized tetradentate phosphine macrocycles with -(CH2)3OCH3 or phenyl groups.
  • Identified that phosphines with -(CH2)3OCH3 groups are not water-soluble.
  • Prepared the macrocyclic phosphine ligand 1,5,9,13-tetraphenyl-1,5,9,13-tetraphosphacycloheptadecane.
  • Synthesized Fe(II) and Co(II) complexes with the prepared macrocyclic phosphine ligand.

Conclusions:

  • Established two viable synthetic routes for tetradentate phosphine macrocycles.
  • Highlighted the effectiveness of Cu(I) templating in macrocyclic phosphine synthesis.
  • Demonstrated the versatility of the synthesized macrocycles in forming metal complexes.