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Draft Genome Sequence of an Atypical Strain of Streptococcus pneumoniae Serotype 19A Isolated from Cerebrospinal

Antonio Ali Perez-Maya1, Rosa Maria Hinojosa-Robles2, Jose Ramon Barcenas-Walls3

  • 1Universidad Autónoma de Nuevo León, Facultad de Medicina, Departamento de Bioquímica y Medicina Molecular, Monterrey, Nuevo León, Mexico.

Genome Announcements
|April 23, 2016
PubMed

Insights

We sequenced the genome of a multidrug-resistant Streptococcus pneumoniae strain from a meningitis case in Mexico. This atypical serogroup 19A strain is the first reported instance of sequence type 3936 in this pathogen.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Streptococcus pneumoniae is a leading cause of bacterial meningitis.
  • Multidrug-resistant strains pose a significant public health threat.
  • Serogroup 19A is an emerging and concerning serotype.

Purpose of the Study:

  • To present the draft genome sequence of a novel Streptococcus pneumoniae strain.
  • To characterize a multidrug-resistant serogroup 19A strain isolated from a meningitis patient.
  • To report the first identification of sequence type 3936 in S. pneumoniae serotype 19A.

Main Methods:

  • Whole-genome sequencing of Streptococcus pneumoniae strain MTY32702340SN814.
  • Bioinformatic analysis for genome assembly and characterization.
  • Serotype and sequence type determination.

Main Results:

  • The draft genome sequence of Streptococcus pneumoniae strain MTY32702340SN814 was successfully generated.
  • The strain was confirmed as multidrug-resistant and belonging to serogroup 19A.
  • Sequence type 3936 was identified, representing a novel finding for this serotype.

Conclusions:

  • The genome sequence provides valuable data for understanding the evolution of multidrug resistance in S. pneumoniae.
  • This study highlights the emergence of atypical and resistant serotypes causing invasive diseases.
  • The identification of ST3936 in serotype 19A warrants further epidemiological surveillance.

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