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Genome Sequence of Foot-and-Mouth Disease Virus Serotype O Isolated from Morocco in 2015

K Bachanek-Bankowska1, J Wadsworth2, A Gray2

  • 1The Pirbright Institute, Pirbright, Woking, Surrey, United Kingdom kasia.bankowska@pirbright.ac.uk.

Genome Announcements
|April 23, 2016
PubMed

Insights

Foot-and-mouth disease (FMD) in Morocco in 2015 was caused by a virus of serotype O, lineage Ind-2001d. This lineage, typically found in South Asia, has recently caused outbreaks in North Africa.

Area of Science:

  • Virology
  • Genomics
  • Epidemiology

Background:

  • Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting cloven-hoofed animals.
  • Outbreaks of FMD pose significant threats to livestock industries and global trade.
  • The Ind-2001d lineage of FMD virus serotype O has been identified as a cause of recent outbreaks.

Purpose of the Study:

  • To describe the genome of a foot-and-mouth disease virus (FMDV) isolate from a 2015 Moroccan outbreak.
  • To characterize the genetic makeup and lineage of the FMDV responsible for the Moroccan outbreak.
  • To understand the epidemiological significance of the Ind-2001d lineage in North Africa.

Main Methods:

  • Viral isolation from clinical samples during the 2015 Moroccan FMD outbreak.
  • Whole-genome sequencing of the isolated FMDV.
  • Phylogenetic analysis to determine the virus's lineage and topotype.

Main Results:

  • The genome of an FMDV isolate from Morocco in 2015 was successfully sequenced.
  • The virus was classified as serotype O, topotype ME-SA (Middle East-South Asia), lineage Ind-2001d.
  • This lineage is endemic to the Indian subcontinent and has been implicated in outbreaks in the Middle East and North Africa since 2013.

Conclusions:

  • The 2015 Moroccan FMD outbreak was caused by the Ind-2001d lineage of FMDV serotype O.
  • The presence of this lineage in North Africa highlights its expanding geographical range.
  • Genomic characterization is crucial for understanding FMDV evolution and spread.

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