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Investigate the relation between Adiponectin gene variants and cardiovascular comorbidities and diabetes

At Eissa1

  • 1Pharmacist and medical student at King Saud Bin Abdulaziz University for Health Sciences.

International Journal of Health Sciences
|April 23, 2016
PubMed

Insights

This study investigated the adiponectin gene

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Metabolic Disorders

Background:

  • Adiponectin gene variants are implicated in various diseases.
  • Understanding their role in cardiovascular disease (CVD) risk factors is crucial.

Purpose of the Study:

  • To investigate the association between adiponectin gene Single Nucleotide Polymorphisms (SNPs) and coronary artery disease (CAD).
  • To examine the relationship between adiponectin gene variants and myocardial infarction (MI), hypertension, and diabetes mellitus in the Saudi population.

Main Methods:

  • A cohort study design was employed using data from the Saudi CAD registry.
  • Genotyping of target SNPs was performed using real-time polymerase chain reaction (PCR).
  • Statistical analysis included Chi-square tests for variable comparisons.

Main Results:

  • No significant association was found between the +45T>G adiponectin gene variant and CAD in the Saudi population.
  • The variant showed no significant link with hypertension or gender.
  • A borderline significant association was observed with myocardial infarction, and a significant association with diabetes mellitus.

Conclusions:

  • The adiponectin gene variant studied showed a significant association with diabetes mellitus in the Saudi population.
  • This finding contrasts with some international studies linking adiponectin to CAD, MI, and hypertension.
Abstract

Keywords:
AdiponectinCardiovascularDiabetesgenetics

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