Stereotactic radiosurgery for intracranial hemangiopericytomas: a multicenter study

Area of Science:

• Neurosurgery
• Radiation Oncology
• Oncology

Background:

• Hemangiopericytomas (HPCs) are rare, aggressive tumors with high recurrence and metastasis rates.
• Effective management strategies for recurrent or newly diagnosed HPCs are critical.

Purpose of the Study:

• To evaluate the efficacy and outcomes of stereotactic radiosurgery (SRS) for HPCs.
• To identify prognostic factors for local tumor control and survival after SRS.

Main Methods:

• A multicenter retrospective study of 90 patients with 133 HPCs treated with SRS (1988-2014).
• Analysis of local tumor control, survival rates, and adverse radiation effects.
• Prognostic variables evaluated using Cox regression and Kaplan-Meier analysis.

Main Results:

• Local tumor control was achieved in 55% of tumors and 62.2% of patients.
• Actuarial overall survival rates were 91.5% at 2 years and 53.7% at 10 years.
• Repeat SRS demonstrated additional benefit for managing recurrences and metastases.

Conclusions:

• SRS provides reasonable local tumor control and a low risk of adverse effects for HPCs.
• Long-term follow-up is essential due to high recurrence and metastasis rates.
• Repeat SRS is an effective option for managing new or recurrent HPCs.