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Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria.

Yangxiaolu Cao1, Marc D Ryser2, Stephen Payne1

  • 1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

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Summary
This summary is machine-generated.

Organ size and body size ratios remain constant due to scale invariance. In engineered bacteria, a collective space-sensing mechanism involving feedback loops controls ring width, ensuring perfect scale invariance to colony size.

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Area of Science:

  • Microbiology
  • Systems Biology
  • Developmental Biology

Background:

  • Scale invariance, maintaining constant organ size to body size ratios, is crucial in development but poorly understood.
  • Engineered Escherichia coli colonies form self-organized core-ring patterns.

Purpose of the Study:

  • To investigate the mechanisms underlying scale invariance in engineered bacterial colonies.
  • To elucidate the role of collective space-sensing in pattern formation and scaling.

Main Methods:

  • Utilized engineered Escherichia coli capable of forming core-ring patterns.
  • Analyzed the relationship between colony size and ring width.
  • Developed a theoretical model of a collective space-sensing mechanism.

Main Results:

  • Demonstrated perfect scale invariance of ring width to colony size in E. coli.
  • Identified a mechanism involving an integral feedback loop and an incoherent feedforward loop.
  • Showcased the importance of timing control in achieving robust pattern scaling.

Conclusions:

  • A collective space-sensing mechanism, integrating feedback and feedforward loops, drives scale invariance in bacterial colony patterns.
  • This mechanism relies on chemical accumulation and nutrient consumption for timing ring initiation.
  • Provides insights into robust pattern scaling and offers a new perspective for studying scale invariance in natural systems.