Functional changes in the inner ear in renal insufficiency. An experimental study in the rat

In acute uremia the auditory brainstem response thresholds in the rat (n = 10) became primarily affected in the low-frequency area. As time elapsed in uremia, even the high-frequency thresholds became impaired. In most animals the latencies for wave 2 at the threshold level increased during the first 48 h concomitant with the impairment of thresholds. After 72 h of uremia, the latencies were shortened as compared with the control values.