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Working with Human Tissues for Translational Cancer Research
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Urate Handling in the Human Body.

David Hyndman1, Sha Liu2, Jeffrey N Miner2

  • 1Ardea Biosciences, Inc., Biology Department, 9390 Towne Centre Drive, San Diego, CA, 92121, USA. DHyndman@ardeabio.com.

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Elevated serum urate concentration causes gout. Understanding urate production, renal, and intestinal elimination is key to gout etiology and treatment. This highlights urate

Keywords:
ExcretionFEUAGoutUrateUric acid

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Metabolic Disorders

Background:

  • Elevated serum urate concentration is the primary cause of gout.
  • Understanding the factors influencing serum urate levels is crucial for gout etiology and treatment strategies.

Purpose of the Study:

  • To explore the complex processes governing urate handling in the human body.
  • To investigate how production, renal elimination, and intestinal elimination of urate impact serum urate concentration.

Main Methods:

  • Review of physiological processes involved in urate metabolism.
  • Analysis of factors affecting urate production and elimination pathways.

Main Results:

  • Urate regulation involves a complex interplay of production, renal, and intestinal elimination.
  • Alterations in any of these processes can significantly affect steady-state serum urate concentration.

Conclusions:

  • The intricate regulation of urate suggests a potential role beyond that of a simple waste product.
  • Further research into urate's complex physiology may reveal novel therapeutic targets for gout.