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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Multiple diaphyseal sclerosis (Ribbing disease): what about neridronate?

M Di Carlo1, F Silveri2, M Tardella2,3

  • 1Rheumatology Department, Polytechnic University of the Marche, c/o Ospedale "Carlo Urbani", Via Aldo Moro, 25, 60035, Jesi (AN), Italy. dica.marco@yahoo.it.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|April 24, 2016
PubMed
Summary

Multiple diaphyseal sclerosis (Ribbing disease) is a rare inherited bone disorder. This case study highlights a patient unresponsive to bisphosphonate treatment, indicating a need for further research.

Keywords:
BisphosphonatesMagnetic resonance imagingNeridronateRibbing disease

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Area of Science:

  • * Orthopedics and Endocrinology
  • * Rare bone diseases and genetic disorders

Background:

  • * Sclerosing bone disorders, such as Multiple Diaphyseal Sclerosis (Ribbing disease), are uncommon and pose diagnostic challenges.
  • * Ribbing disease is an inherited condition characterized by excessive bone tissue proliferation in the diaphyses of long bones.

Observation:

  • * Conventional radiology shows cortical thickening, bone scintigraphy reveals abnormal tracer concentration, and MRI confirms sclerosis with bone marrow edema.
  • * Treatment is empirical due to unknown pathophysiology, often involving glucocorticoids or bisphosphonates.

Findings:

  • * A patient with Ribbing disease demonstrated a lack of response to one year of intravenous neridronate treatment.
  • * Pain and bone marrow edema persisted despite bisphosphonate therapy.

Implications:

  • * The findings suggest potential limitations of bisphosphonates in treating Ribbing disease.
  • * Further research into the pathophysiology and alternative treatments for this rare condition is warranted.