Transient disappearance of microbleeds in the subacute period based on T2*-weighted gradient echo imaging in

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Jun Watanabe1, Jun Maruya2, Yu Kanemaru3

  • 1Department of Neurosurgery, Akita Red Cross Hospital, 222-1 Nawashirosawa, Saruta, Kamikitate, Akita, 010-1495, Japan. watanabejun1003@yahoo.co.jp.

Acta Neurochirurgica
|April 24, 2016
PubMed

Insights

Traumatic microbleeds show dynamic changes on T2* gradient echo imaging (T2*GEI) over time. Lesions initially appear hyper-acute, then fade, and reappear in the chronic stage, suggesting evolving susceptibility effects.

Area of Science:

  • Neuroimaging
  • Radiology
  • Trauma Imaging

Background:

  • Traumatic brain injury (TBI) can cause microbleeds, which are challenging to monitor over time.
  • Gradient echo imaging (GEI) is sensitive to magnetic susceptibility effects caused by blood products.

Observation:

  • Three cases of traumatic microbleeds were sequentially observed using T2*-weighted GEI (T2*GEI).
  • Hypo-intensities, indicative of microbleeds, were present 2-3 hours post-injury (hyper-acute).
  • These hypo-intensities became obscure or disappeared between 2-6 days (subacute) but reappeared clearly 1-3 months later (chronic).

Findings:

  • Microbleed visibility on T2*GEI is not static but changes dynamically throughout the healing process.
  • The observed dynamic changes in hypo-intensities correlate with the age of the hematoma.
  • Differences in susceptibility effects related to hematoma degradation likely cause these temporal variations.

Implications:

  • Sequential T2*GEI can provide valuable insights into the evolution of traumatic microbleeds.
  • Understanding these dynamic changes may improve the interpretation of imaging findings in TBI.
  • This highlights the importance of considering the timing of imaging in relation to injury for accurate microbleed assessment.
Keywords:
Diffuse axonal injuryMagnetic resonance imagingMicrobleedsT2*-weighted gradient echo imagingTraumatic brain injury

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