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Imaging and Analysis of Neurofilament Transport in Excised Mouse Tibial Nerve

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Diffusion tensor imaging of peripheral nerves in non-fixed post-mortem subjects.

Wieke Haakma¹, Michael Pedersen², Martijn Froeling³

¹Department of Forensic Medicine, Aarhus University, Aarhus, Denmark; Comparative Medicine Lab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Forensic Science International

|April 25, 2016

Summary

Post-mortem diffusion tensor imaging (DTI) and fiber tractography (FT) are reproducible for analyzing lumbosacral nerves. This advanced MRI technique can identify nerve trauma and pathologies in forensic investigations.

Keywords:

Diffusion tensor imaging Fiber tractography Magnetic resonance imaging Peripheral nerves Post-mortem imaging

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Area of Science:

Forensic Science
Neuroimaging
Biomedical Engineering

Background:

Standard magnetic resonance imaging (MRI) is used in post-mortem (PM) examinations.
Advanced MRI techniques like diffusion tensor imaging (DTI) are underutilized in forensic science.

Purpose of the Study:

To assess the temporal stability and reproducibility of DTI and fiber tractography (FT) in non-fixed PM subjects.
To investigate lumbosacral nerves using PMDTI and compare findings with in vivo data.

Main Methods:

Acquired MRI data from seven PM and six living subjects.
Evaluated reproducibility of fractional anisotropy (FA) and mean diffusivity (MD) for lumbosacral nerves using Bland-Altman and Jones plots.
Compared PM nerve diffusion parameters to in vivo data using the Mann-Whitney U test.

Main Results:

DTI showed good inter-scan and inter-session reproducibility for FA and MD in PM subjects.
PM subjects exhibited lower diffusivity values (approx. four-fold) compared to living subjects.
FT successfully reconstructed nerve architecture, and PMDTI identified nerve lesions in a chronic trauma case.

Conclusions:

DTI and FT are reproducible for characterizing PM nervous tissue properties and reconstructing nerve architecture.
PMDTI and FT can differentiate between PM and in vivo diffusion values and detect nerve trauma.
PMDTI and FT show potential as valuable tools for identifying and documenting PM nerve trauma and pathologies in forensic science.