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Related Experiment Video

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Inherited renal carcinomas.

Akira Kawashima1, Scott W Young2, Naoki Takahashi3

  • 1Departments of Radiology, Mayo Clinic in Scottsdale, AZ, 13400 E Shea Blvd., Scottsdale, AZ, 85259, USA. Kawashima.Akira@mayo.edu.

Abdominal Radiology (New York)
|April 25, 2016
PubMed
Summary
This summary is machine-generated.

Hereditary kidney cancer syndromes, linked to specific gene mutations, often present with multiple tumors and extrarenal symptoms. Radiology plays a key role in diagnosing and managing these inherited renal cell carcinoma conditions.

Keywords:
Birt–Hogg–DubéHereditary leiomyomatosis renal cell carcinomaHereditary papillary renal carcinomaInherited renal carcinomasLynch syndromeTuberous sclerosis complexvon Hippel–Lindau

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Area of Science:

  • Oncology
  • Genetics
  • Radiology

Background:

  • Hereditary kidney carcinomas comprise 5-8% of renal neoplasms.
  • These tumors are frequently bilateral, multiple, and diagnosed at younger ages.
  • Specific gene mutations and histologic subtypes characterize each hereditary syndrome.

Purpose of the Study:

  • To review the clinical and imaging findings of inherited kidney cancer syndromes.
  • To highlight the role of radiology in the management of these conditions.

Main Methods:

  • Review of clinical and imaging findings.
  • Discussion of well-defined inherited kidney cancer syndromes.

Main Results:

  • Hereditary syndromes present with distinct genetic mutations, histologic types, and extrarenal manifestations.
  • Radiology is crucial for screening and managing patients.

Conclusions:

  • Recognizing associated extrarenal findings aids in identifying hereditary kidney cancer syndromes.
  • Radiological assessment is fundamental for the diagnosis and surveillance of patients with inherited renal cell carcinoma.