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Cerebral structure in borderline personality disorder.

P B Lucas1, D L Gardner, R W Cowdry

  • 1University of California, Los Angeles.

Psychiatry Research
|February 1, 1989
PubMed
Summary

Computed tomographic (CT) scans revealed no significant structural brain differences in patients with borderline personality disorder (BPD). While subtle neurological dysfunction is possible, BPD is not associated with major brain pathology.

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurology

Background:

  • Borderline personality disorder (BPD) is a complex mental health condition.
  • Previous research has explored potential neurological underpinnings of BPD.
  • Structural brain abnormalities have been investigated as a possible factor.

Purpose of the Study:

  • To investigate structural brain differences in individuals with BPD.
  • To compare brain imaging metrics between BPD patients and healthy controls.
  • To assess for ventricle-brain ratios, third ventricular size, and frontal lobe atrophy.

Main Methods:

  • Utilized computed tomographic (CT) scans for brain imaging.
  • Analyzed quantitative measures including ventricle-brain ratios.

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  • Examined third ventricular size and evidence of frontal lobe atrophy.

    • Main Results:

    • No significant differences in ventricle-brain ratios or frontal lobe atrophy were found between groups.
    • A narrower third ventricle was observed in borderline personality disorder patients.
    • This finding was largely attributable to a narrower third ventricle in female subjects overall.

    Conclusions:

    • Borderline personality disorder is not associated with significant structural brain pathology.
    • Subtle neurological dysfunction may be present in BPD, but not indicative of gross structural changes.
    • Neuroimaging studies do not support major brain structural abnormalities as a primary feature of BPD.