Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mitigating dithiothreitol interference to gold/thiol interface in electrochemical detection of cathepsin B activity toward multiplex protease analysis.

Biosensors & bioelectronics·2025

Same author

Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes.

Journal of animal science and biotechnology·2024

Same author

Enhanced Electron Transfer Rates by AC Voltammetry for Ferrocenes Attached to the End of Embedded Carbon Nanofiber Nanoelectrode Arrays.

Electroanalysis·2023

Same author

Synthesis of Chiral Tricyclic Pyrone Molecules via Palladium(0)-Catalyzed Displacement Reactions of Chiral Tricyclic Pyrone Acetate With Azide or Amine.

ChemistrySelect·2023

Same author

Indication of Pd-C or Cu-C Intermediate in Respective Bimetallic Nanoclusters Pd/Au-PVP or Cu/Au-PVP Catalyzed Oxidations of <i>endo</i>-4-Oxatricyclo[5.2.1.0<sup>2,6</sup>]-8-decene and Tetrahydro-γ-carbolines.

Synthesis·2023

Same author

Chirality-driven self-assembly: application toward renewable/exchangeable resin-immobilized catalysts.

Organic & biomolecular chemistry·2022

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity

Published on: November 16, 2017

Current tools for norovirus drug discovery.

Sahani Weerasekara¹, Allan M Prior², Duy H Hua¹

¹a Department of Chemistry , Kansas State University , Manhattan , KS , USA.

Expert Opinion on Drug Discovery

|April 26, 2016

Summary

Norovirus causes severe gastroenteritis, and new treatments are urgently needed. Research is advancing the discovery of small molecule inhibitors targeting viral proteins and entry, offering hope for effective therapies.

Keywords:

3CLpro Gastroenteritis norovirus polymerase inhibitors protease inhibitors proteases virus entry

More Related Videos

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography

Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography

Published on: April 19, 2016

Related Experiment Videos

Last Updated: Mar 22, 2026

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity

Published on: November 16, 2017

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography

Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography

Published on: April 19, 2016

Area of Science:

Virology
Drug Discovery
Gastroenterology

Background:

Norovirus rapidly transmits due to low infectious dose, high genetic diversity, and short incubation.
It causes acute gastroenteritis, with no FDA-approved vaccines or specific drugs currently available.
Advances in cell and animal models facilitate the discovery of novel antiviral agents.

Purpose of the Study:

To review the current state of norovirus drug discovery.
To highlight the identification and development of anti-norovirus molecules.
To discuss strategies for effective norovirus counteraction.

Main Methods:

Review of norovirus biology and replication.
Discussion of targeting the viral life cycle, including structural and nonstructural proteins (proteases, polymerase).
Examination of virus entry inhibition and drugs in clinical development.

Main Results:

Current strategies focus on inhibiting viral RNA polymerase, 3C-like protease, and structural protein VP1.
Broad-spectrum inhibitors targeting 3CL protease have been developed.
Research is exploring host factors and resistance mechanisms.

Conclusions:

A dual approach targeting viral and host factors may effectively counteract norovirus.
Development of replicon cell lines and animal models has accelerated drug discovery.
Further research is needed to overcome viral mutations and resistance.