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Updated: Mar 22, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
A comparative study between propofol and etomidate in patients under general anesthesia.
Supriya Aggarwal1, Vipin Kumar Goyal1, Shashi Kala Chaturvedi1
1Department of Anesthesia and Critical care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
Etomidate offers superior hemodynamic stability and less injection pain compared to propofol for anesthesia induction. This makes etomidate a safer choice for patients undergoing general anesthesia.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Anesthesia induction is critical, with risks of hypotension and cardiovascular collapse in unstable patients.
- Safe induction agents with minimal adverse effects are needed.
Purpose of the Study:
- Compare propofol and etomidate for anesthesia induction.
- Evaluate hemodynamic effects and adverse events of these agents.
Main Methods:
- Prospective randomized study of 100 ASA I/II patients (18-60 years).
- Patients received either propofol (2mg/kg) or etomidate (0.3mg/kg).
- Monitored vital signs and adverse effects like pain, apnea, and myoclonus.
Main Results:
- Etomidate group showed minimal changes in mean arterial pressure and heart rate versus propofol.
- Propofol caused more pain on injection.
- Etomidate was associated with higher incidence of myoclonus.
Conclusions:
- Etomidate demonstrates better hemodynamic stability during anesthesia induction.
- Etomidate is preferable to propofol due to reduced injection pain and maintained hemodynamics.
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