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Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
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[Refractive development and form-deprivation induced myopic refractive error in CBA/CaJ mice]
Yun-Yun Li1, Kang-Wei Qian1, Xiao-Hua Wu1
1Institute of Neurobiology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Sheng Li Xue Bao : [Acta Physiologica Sinica]
|April 26, 2016
Summary
The CBA/CaJ mouse, which synthesizes melatonin, shows normal refractive development and can be used as a myopia model. Form-deprivation in this strain induced significant myopia, confirming its utility for myopia research.
Area of Science:
- Ophthalmology
- Genetics
- Neuroscience
Background:
- Mice are key mammalian models for myopia research due to genetic manipulation advantages.
- Most lab mice lack melatonin synthesis, a hormone potentially involved in human myopia.
- CBA/CaJ mice are melatonin-proficient, making them a unique model for myopia studies.
Purpose of the Study:
- Investigate refractive development in melatonin-proficient CBA/CaJ mice.
- Determine if CBA/CaJ mice are suitable for myopia research.
- Assess the impact of form-deprivation on refractive development in CBA/CaJ mice.
Main Methods:
- Eccentric infrared photoretinoscopy used for stable refraction measurements.
- Refractive development tracked in CBA/CaJ mice from 3 weeks of age.
- Form-deprivation induced using translucent occluders for 5 weeks in 3-week-old mice.
Main Results:
- CBA/CaJ mice exhibited age-related hyperopic shifts, stabilizing around 9 weeks.
- Refractive error values were higher in CBA/CaJ mice compared to C57BL/6 mice.
- Form-deprivation caused a significant myopic shift in CBA/CaJ mice.
Conclusions:
- CBA/CaJ mice demonstrate stable refractive development and are suitable for myopia research.
- Form-deprivation successfully induced myopia in CBA/CaJ mice.
- This strain offers a valuable model for studying myopia mechanisms, particularly those involving melatonin.
