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Related Experiment Video

Updated: Mar 22, 2026

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
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Translational issues for human corneal endothelial tissue engineering.

Yu Qiang Soh1,2, Gary S L Peh1,3, Jodhbir S Mehta1,2,3,4

  • 1Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore.

Journal of Tissue Engineering and Regenerative Medicine
|April 26, 2016
PubMed
Summary
This summary is machine-generated.

Corneal endothelial cell therapy offers a promising alternative to corneal transplantation for treating endothelial disorders. This review updates translational challenges and progress in developing cell-based therapies for corneal blindness.

Keywords:
cell markerscorneaendothelial-mesenchymal transitionendotheliumhuman corneal endothelial cellskeratoplasty

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Corneal endothelial disorders cause significant visual impairment and blindness.
  • Corneal transplantation is the primary treatment but faces a global donor tissue shortage.
  • An aging population exacerbates the demand-supply gap for corneal grafts.

Purpose of the Study:

  • To review the translational challenges in human corneal endothelial cell therapy.
  • To update on recent advancements in cell culture and translational strategies.
  • To assess the progress towards cell-based tissue engineering for corneal diseases.

Main Methods:

  • Review of current literature on corneal endothelial cell therapy.
  • Analysis of translational issues in clinical application.
  • Evaluation of cell culture techniques and tissue engineering approaches.

Main Results:

  • Significant progress in corneal endothelial cell culture techniques.
  • Advancements in translational strategies for cell-based therapies.
  • Growing potential for cell-based tissue engineering to treat corneal diseases.

Conclusions:

  • Human corneal endothelial cell therapy is a viable alternative to transplantation.
  • Overcoming translational hurdles is key to clinical success.
  • Cell-based approaches represent the future of treating corneal endothelial diseases.