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Updated: Mar 22, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
[Sudden cardiovascular death in adults: Study of 361 autopsy cases]
M A Mesrati1, M Belhadj1, A Aissaoui1
1Service de médecine légale, CHU Fattouma Bourguiba, Monastir, Tunisie; Faculté de médecine, université de Monastir, Monastir, Tunisie.
Insights
Sudden cardiovascular death, often due to myocardial infarction, predominantly affects middle-aged men. Understanding its causes is crucial for prevention strategies.
Area of Science:
- Cardiology
- Forensic Medicine
- Epidemiology
Background:
- Sudden cardiovascular death (SCD) is a significant public health concern.
- Identifying epidemiological and etiopathogenic factors is essential for targeted prevention.
Purpose of the Study:
- To delineate the epidemiological profile of SCD.
- To elucidate the underlying etiopathogenic characteristics of SCD.
Main Methods:
- Retrospective, descriptive study design.
- Analysis of 361 autopsy cases of SCD over eight years (2004-2011).
- Conducted at the forensic medicine department of Monastir.
Main Results:
- SCD incidence reported at 9 per 100,000 person-years.
- Predominantly observed in males, with a mean age of 55.75 years.
- Myocardial infarction was the leading cause (57.8%), followed by other cardiac and non-cardiac conditions.
Conclusions:
- SCD is frequently a complication of previously unrecognized heart disease.
- Multiple risk factors contribute to SCD.
- Prevention requires a multidisciplinary approach involving various medical specialists and public awareness.
Aims Of The Study:
To describe epidemiological aspects of sudden cardiovascular death and to specify the etiopathogenic characteristics.
Patients And Method:
Our study is retrospective and descriptive. It included 361 cases of sudden cardiovascular death, which underwent autopsy in forensic medicine department of Monastir during eight years, from 1st January 2004 to 31st December 2011.
Results:
The incidence of sudden cardiovascular death was 9 per 100,000 person. A marked male predominance was noted. The mean age was 55.75 years. In our series, myocardial infarction represents the leading cause of sudden cardiovascular death, 57.8% of cases. Other etiologies were hypertrophic cardiomyopathy (4.7%), heart failure (1.9%), arrhythmogenic right ventricular dysplasia (2.8%), valvular disease (2%), cardio-myo-pericarditis (1.9%), hydatid cyst of the heart (0.8%), ruptured aneurysm (2.5%), pulmonary embolism (1.9%) and aortic dissection (1.3%). A sudden cardiovascular death at work was found in 25 cases. These cases pose essentially a problem of imputability.
Conclusion:
Sudden cardiac death is usually the complication of underlying heart disease, sometimes overlooked. Several risk factors are involved. Sudden cardiac death in healthy heart or death caused by arrhythmia is an important entity seeking the intervention of several actors (forensic doctor, cardiologist, geneticist, media…) for prevention.
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