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Related Experiment Video

Updated: Mar 22, 2026

Selection of Aptamers for Amyloid &#946;-Protein, the Causative Agent of Alzheimer's Disease
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Aptamers: The "evolution" of SELEX.

Yi Xi Wu1, Young Jik Kwon2

  • 1Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, United States.

Methods (San Diego, Calif.)
|April 26, 2016
PubMed
Summary

Aptamer molecules offer versatile binding for pharmaceuticals and biosensors. New methods like automation and single-round SELEX are improving aptamer discovery, overcoming previous limitations.

Keywords:
AptamersSELEX

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Discovery

Background:

  • Aptamer molecules, discovered over two decades ago, have garnered significant scientific interest.
  • Their ability to bind diverse targets, malleability, and cost-effective production make them valuable in pharmaceuticals and biosensors.

Purpose of the Study:

  • To highlight the potential of aptamer technology.
  • To address the challenges hindering aptamer application, including tedious procedures, high resource use, and limited nucleobase options.

Main Methods:

  • Development of innovative methodologies for aptamer discovery.
  • Implementation of automation and single-round SELEX (Systematic Evolution of Ligands by Exponential Enrichment).

Main Results:

  • These advancements aim to enhance the efficiency and speed of aptamer discovery.
  • Improved outcomes in identifying functional aptamers for various applications.

Conclusions:

  • Aptamer technology holds significant promise for pharmaceutical and biosensor development.
  • Ongoing innovation in discovery methods is crucial for overcoming existing limitations and expanding aptamer utility.