Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Periodontal Treatment Reduces Circulating Pro-Inflammatory Cytokine and Chemokine Levels in African American HIV+ Individuals with Virological Suppression.

Journal of dental applications·2022
Same author

Management of well appearing infants born to afebrile mothers with inadequate GBS prophylaxis: A retrospective comparison of the three approaches recommended by the COFN.

Journal of neonatal-perinatal medicine·2021
Same author

Distinct Microbial Signatures between Periodontal Profile Classes.

Journal of dental research·2021
Same author

Gender Inequalities in the Dental Workforce: Global Perspectives.

Advances in dental research·2019
Same author

The Association between the History of HIV Diagnosis and Oral Health.

Journal of dental research·2016
Same author

Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes.

Oral diseases·2016

Related Experiment Video

Updated: Jul 21, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.1K

Hairy leukoplakia; lessons learned: 30-plus years.

J S Greenspan1, D Greenspan1, J Webster-Cyriaque2

  • 1Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.

Oral Diseases
|April 26, 2016
PubMed
Summary

Oral hairy leukoplakia (HL), initially linked to HIV/AIDS, is now understood to affect individuals beyond the HIV spectrum. Its association with Epstein-Barr virus (EBV) and management are key considerations.

Keywords:
Epstein-Barr virusHIV/AIDShairy leukoplakiaoral lesions

More Related Videos

Generation of Organotypic Raft Cultures from Primary Human Keratinocytes
07:26

Generation of Organotypic Raft Cultures from Primary Human Keratinocytes

Published on: February 22, 2012

19.9K
Plaquing of Herpes Simplex Viruses
04:41

Plaquing of Herpes Simplex Viruses

Published on: November 5, 2021

7.3K

Related Experiment Videos

Last Updated: Jul 21, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.1K
Generation of Organotypic Raft Cultures from Primary Human Keratinocytes
07:26

Generation of Organotypic Raft Cultures from Primary Human Keratinocytes

Published on: February 22, 2012

19.9K
Plaquing of Herpes Simplex Viruses
04:41

Plaquing of Herpes Simplex Viruses

Published on: November 5, 2021

7.3K

Area of Science:

  • Oral medicine
  • Virology
  • Immunology

Background:

  • The HIV/AIDS pandemic has revealed numerous oral manifestations.
  • Oral hairy leukoplakia (HL) is a significant oral lesion associated with Epstein-Barr virus (EBV).
  • Initially observed primarily in individuals with HIV/AIDS, HL's prevalence is now recognized to extend beyond this population.

Purpose of the Study:

  • To review the clinical and histological features of oral hairy leukoplakia (HL).
  • To explore the discovery, cause, diagnosis, and pathogenesis of HL.
  • To discuss the relationship between HL, HIV/AIDS, Epstein-Barr virus (EBV) biology, and the impact of HIV/AIDS therapy.

Main Methods:

  • Literature review of clinical and histological data on oral hairy leukoplakia.
  • Analysis of the association between HL, Epstein-Barr virus (EBV), and HIV/AIDS.
  • Examination of diagnostic criteria and management strategies for HL.

Main Results:

  • Oral hairy leukoplakia (HL) is an Epstein-Barr virus (EBV)-associated oral lesion.
  • HL is not exclusive to individuals with HIV/AIDS, with a broader distribution observed.
  • Understanding HL's pathogenesis and its changes with HIV/AIDS therapy is crucial.

Conclusions:

  • Oral hairy leukoplakia (HL) is an important oral manifestation linked to Epstein-Barr virus (EBV).
  • The scope of HL extends beyond the HIV/AIDS spectrum.
  • Further research into HL's pathogenesis and management, especially in the context of evolving HIV/AIDS therapies, is warranted.