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What Is the Effect of Metabolic Syndrome without Hypertension on Left Ventricular Hypertrophy?

Mohammad M Al-Daydamony1, Mohammad El-Tahlawi2

  • 1Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Echocardiography (Mount Kisco, N.Y.)
|April 26, 2016
PubMed

Insights

Metabolic syndrome (MetS) increases left ventricular hypertrophy (LVH) even without hypertension. MetS patients showed higher LV mass and wall thickness, linked to glucose, HbA1c, triglycerides, and obesity.

Area of Science:

  • Cardiology
  • Metabolic Diseases
  • Clinical Research

Background:

  • Left ventricular hypertrophy (LVH) is a key risk factor for cardiovascular events.
  • Metabolic syndrome (MetS) is strongly linked to LVH in hypertensive individuals.
  • The association between MetS and LVH without hypertension remains understudied.

Purpose of the Study:

  • To investigate the impact of MetS on left ventricular (LV) mass in non-hypertensive patients.
  • To determine if MetS contributes to LVH independent of elevated blood pressure.

Main Methods:

  • Fifty MetS patients without hypertension and 50 healthy controls were recruited.
  • Evaluations included electrocardiography, laboratory tests, and echocardiography.
  • Measurements assessed LV dimensions, function, mass, and mass index (LVMI).

Main Results:

  • No significant differences in LV diastolic or systolic dimensions, or ejection fraction were observed.
  • MetS patients exhibited significantly higher LV posterior wall thickness, LV mass, and LVMI.
  • LVMI correlated positively with glucose, HbA1c, triglycerides, and obesity, and negatively with HDL-C.

Conclusions:

  • MetS is associated with increased LV wall thickness, LV mass, and LVMI, even in the absence of hypertension.
  • These findings highlight MetS as an independent risk factor for LVH.
  • Metabolic parameters like glucose and triglycerides are significant predictors of LVH in this population.
Abstract

Keywords:
diabetes mellitusdyslipidemiaechocardiographyleft ventricular hypertrophyleft ventricular massmetabolic syndrome

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