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Nanoparticle Enhanced Laser-Induced Breakdown Spectroscopy for Microdrop Analysis at subppm Level.

Alessandro De Giacomo1,2, Can Koral1, Gabriele Valenza1,2

  • 1University of Bari , Department of Chemistry, Via Orabona 4, 70126 Bari, Italy.

Analytical Chemistry
|April 26, 2016
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Summary

Nanoparticle enhanced laser-induced breakdown spectroscopy (NELIBS) significantly improves elemental analysis sensitivity. This technique achieves picogram-level detection limits for elements like lead and silver in various solutions.

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Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Nanotechnology

Background:

  • Laser-induced breakdown spectroscopy (LIBS) faces limitations in detecting low analyte concentrations.
  • Sub-parts-per-million (subppm) detection requires enhanced analytical techniques.

Purpose of the Study:

  • To apply nanoparticle enhanced laser-induced breakdown spectroscopy (NELIBS) for elemental analysis of microdrop solutions.
  • To improve the sensitivity and lower the limit of detection (LOD) of LIBS.

Main Methods:

  • Utilized nanoparticle enhanced laser-induced breakdown spectroscopy (NELIBS).
  • Investigated the effect of local electromagnetic field enhancement on laser ablation and optical emission.
  • Analyzed microdrops of solutions, including biological samples like protein solutions and human serum.

Main Results:

  • Achieved over a 1-order-of-magnitude enhancement in optical emission signal.
  • Demonstrated sub-parts-per-billion (ppb) quantification capabilities.
  • Reached absolute LODs of a few picograms for lead (Pb) and 0.2 pg for silver (Ag).
  • Observed significant sensitivity improvements in biological samples compared to conventional LIBS.

Conclusions:

  • NELIBS offers a substantial improvement in sensitivity for elemental chemical analysis.
  • The technique effectively lowers the limit of detection (LOD) for trace elements.
  • NELIBS demonstrates potential for analyzing challenging biological matrices with enhanced sensitivity.