Related Experiment Video
Updated: Mar 22, 2026
06:48
Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
Published on: July 25, 2014
13.9K
A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab
1Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan.
Transplantation Proceedings
|April 26, 2016
Summary
Adalimumab effectively treated severe acute cellular rejection (ACR) in a small bowel transplant (SBT) patient refractory to standard therapies. This case study suggests adalimumab as a potential treatment for ACR after intestinal transplantation.
Area of Science:
- Gastroenterology
- Transplant Surgery
- Immunology
Background:
- Acute cellular rejection (ACR) occurs more frequently in small bowel transplantation (SBT) than other solid organ transplants.
- Standard treatments for ACR can be ineffective in some cases, necessitating alternative therapeutic strategies.
Observation:
- A female patient with Crohn's disease underwent SBT and developed severe ACR resistant to initial treatments including methylprednisolone, thymoglobulin, basiliximab, and tacrolimus adjustments.
- Repeat endoscopies and biopsies showed no improvement despite standard care.
Findings:
- The patient was treated with adalimumab every two weeks for six months, alongside maintenance prednisone and tacrolimus.
- Subsequent evaluations demonstrated significant improvement, with normal mucosa and villi observed on biopsies, indicating successful resolution of ACR.
Implications:
- This case suggests that adalimumab can be a viable therapeutic option for managing refractory ACR in intestinal transplant recipients.
- Further multicenter studies are warranted to confirm the efficacy and optimal use of adalimumab in this patient population.
Related Concept Videos
01:40Cell-mediated Immune Responses
86.0K
Overview
86.0K
01:26Kidney Transplant II: Surgical Procedure
739
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
739
01:24Tissue Transplantation
1.2K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
722
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
722
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
655
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
655
01:16Kidney Transplant III: Nursing Management
543
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
543