Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substituent-Dependent Turn Switching in RGGY Peptidomimetics Containing Alkene Dipeptide Isosteres.

The Journal of organic chemistry·2026
Same author

Photocatalyzed Reductive Ring-Opening of γ-(2-Chloroaziridinyl)acrylates Using Dihydropyridines: Access to (<i>Z</i>)-Chloroalkene Dipeptide Isosteres.

The Journal of organic chemistry·2026
Same author

An <i>o</i>-Nitroveratryloxycarbonyl-Based Photolabile Solubilizing Tag for the Chemical Synthesis of Poorly Soluble Peptides and Proteins.

Organic letters·2026
Same author

2-Mercaptophenylboronic acid: a superior alternative to 2-mercaptoethanol for thioester hydrolysis.

Organic & biomolecular chemistry·2026
Same author

Strategic alkene incorporation into peptide backbones to prevent enzymatic hydrolysis by evading molecular recognition.

Chemical communications (Cambridge, England)·2026
Same author

In vitro Anti-aging Effect via Sirtuin-1 Modulation and Enhancement of Resveratrol Pharmacokinetics in Gnetum gnemon L. Hard Shell Nanoextract.

Pharmaceutical nanotechnology·2026
Same journal

Antibacterial Activity of Hen Egg White Lysozyme Denatured by Thermal and Chemical Treatments.

Scientia pharmaceutica·2018
Same journal

Isothiochromenothiazoles-A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of <i>Trypanosoma brucei brucei</i>.

Scientia pharmaceutica·2018
Same journal

NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells.

Scientia pharmaceutica·2018
Same journal

In Vivo Evaluation of <i>Antirrhinum majus</i>' Wound-Healing Activity.

Scientia pharmaceutica·2018
Same journal

Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma.

Scientia pharmaceutica·2018
Same journal

Pharmacokinetic Enhancers (Boosters)-Escort for Drugs against Degrading Enzymes and Beyond.

Scientia pharmaceutica·2018
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

9.5K

Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation.

Heni Rachmawati1, Yulia L Yanda1, Annisa Rahma1

  • 1School of Pharmacy, Bandung Institute of Technology, Ganesha 10, 40322, Bandung, Indonesia.

Scientia Pharmaceutica
|April 26, 2016
PubMed
Summary
This summary is machine-generated.

Nanoencapsulation of curcumin in poly(lactic acid) nanoparticles significantly enhances its bioavailability. This study optimized parameters to create effective curcumin-loaded nanoparticles for improved therapeutic potential.

Keywords:
CurcuminNanoparticle formulationPLATPGSpoly(lactic acid)

More Related Videos

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.6K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.4K

Related Experiment Videos

Last Updated: Mar 22, 2026

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

9.5K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.6K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.4K

Area of Science:

  • Pharmacology
  • Materials Science
  • Nanotechnology

Background:

  • Curcumin, a compound from Curcuma domestica, exhibits anti-inflammatory, antioxidant, and anticarcinogenic properties.
  • Poor bioavailability limits curcumin's therapeutic efficacy despite its safety in human trials.
  • Nanoencapsulation in biodegradable polymers offers a strategy to overcome curcumin's bioavailability challenges.

Purpose of the Study:

  • To encapsulate curcumin into poly(lactic acid) (PLA) nanoparticles using an emulsification-solvent evaporation method.
  • To optimize formulation parameters for enhanced nanoparticle characteristics.
  • To evaluate the physicochemical properties of the curcumin-loaded PLA nanoparticles.

Main Methods:

  • Emulsification-solvent evaporation technique was employed for curcumin encapsulation in PLA nanoparticles.
  • Key parameters including solvent type, surfactant concentration, drug loading, sonication time, and centrifugation speed were optimized.
  • Physicochemical characterization involved particle size, polydispersity index, zeta potential, Differential Scanning Calorimetry (DSC), and X-Ray Diffraction (XRD) analysis.

Main Results:

  • Optimized conditions yielded spherical nanoparticles with an average size below 300 nm.
  • The highest encapsulation efficiency of 89.42 ± 1.04% was achieved with 5% curcumin loading.
  • Characterization revealed particle size of 387.50 ± 58.60 nm, polydispersity index of 0.289 ± 0.047, and zeta potential of -1.12 mV for 5% curcumin-PLA nanoparticles.
  • DSC and XRD studies indicated partial interaction between curcumin and the PLA polymer.

Conclusions:

  • Poly(lactic acid) nanoparticles effectively encapsulate curcumin, improving its potential for therapeutic applications.
  • The optimized emulsification-solvent evaporation method provides a viable approach for producing curcumin-loaded nanoparticles.
  • Further studies are warranted to explore the in vivo efficacy and safety of these nano-formulated curcumin delivery systems.