Related Experiment Video
Updated: Aug 17, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
An application of a mathematical model to adjust for time lag in case reporting
Abstract:
In a dynamic, fluctuating surveillance system, the time lag of case reporting often causes an artificial plateau in an epidemic curve. Arbitrarily ignoring data reported in the most recent period to avoid this bias causes the loss of valuable information. In this report, we propose an application of a mathematical model to adjust for the underreporting bias owing to the time lag of the reporting process. We present an example using the acquired immunodeficiency syndrome incidence data for the homosexual group in the San Francisco surveillance system to illustrate and evaluate prospectively this proposed technique. The results show that the adjusted incidence obtained with the model agrees reasonably well with the true incidence, except for the last month of the period under consideration.
Related Concept Videos
Pharmacokinetic Models: Overview
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model
Steps in Outbreak Investigation
Mathematical Modeling: Problem Solving

