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Oxidative Stress Predicts All-Cause Mortality in HIV-Infected Patients

Mar Masiá1, Sergio Padilla1, Marta Fernández2

  • 1Infectious Diseases Unit, Hospital General de Elche, Universidad Miguel Hernández, Alicante, Spain.

Plos One
|April 26, 2016
PubMed

Insights

Oxidative stress markers, including F2-isoprostanes (F2-IsoPs), predict mortality in HIV-infected patients. This association is independent of HIV factors and inflammation, highlighting oxidative stress as a key risk factor.

Area of Science:

  • Biomedical research
  • Infectious diseases
  • Cardiovascular health

Background:

  • HIV infection is associated with increased oxidative stress.
  • Oxidative stress may contribute to long-term complications and mortality in HIV patients.
  • Identifying predictors of mortality is crucial for managing HIV.

Purpose of the Study:

  • To determine if oxidative stress markers predict all-cause mortality in HIV-infected patients.
  • To investigate the relationship between plasma F2-isoprostanes (F2-IsoPs) and malondialdehyde (MDA) and mortality.
  • To assess if these associations are independent of HIV-related factors and inflammation.

Main Methods:

  • Nested case-control study within the CoRIS cohort of antiretroviral-naïve HIV patients.
  • Measured plasma F2-IsoPs and MDA levels in 54 cases (deceased) and 93 matched controls.
  • Adjusted for age, HIV factors, CD4 count, viral load, and highly-sensitive C-reactive protein (hsCRP).

Main Results:

  • Significantly higher median F2-IsoPs and MDA levels in cases compared to controls.
  • F2-IsoPs remained a significant predictor of mortality after adjustment (aOR, 2.34; P=0.009).
  • MDA association with mortality was attenuated after adjustment (aOR, 2.05; P=0.080). hsCRP also predicted mortality.

Conclusions:

  • Oxidative stress, particularly elevated F2-IsoPs, is an independent predictor of all-cause mortality in HIV-infected individuals.
  • The association of F2-IsoPs with mortality is not explained by HIV-specific factors or subclinical inflammation.
  • These findings underscore the importance of addressing oxidative stress in HIV management.
Abstract

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