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Predictive value of newly defined CHA2DS2-VASc-HSF score for severity of coronary artery disease in ST segment

Onur Kadir Uysal1, Caner Turkoglu, Mustafa Duran

  • 1Adana Numune Education and Research Hospital, Adana, Turkey. onurkadir@gmail.com.

Kardiologia Polska
|April 27, 2016
PubMed

Insights

The CHA2DS2-VASc-HSF score effectively predicts coronary artery disease (CAD) severity in ST-segment elevation myocardial infarction (STEMI) patients. This score aids in assessing atherosclerosis extent, crucial for STEMI management.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Clinical Risk Stratification

Background:

  • Established risk scores like CHADS2 and CHA2DS2-VASc share factors with coronary artery disease (CAD) development.
  • The CHA2DS2-VASc-HSF score incorporates factors known to promote atherosclerosis and CAD severity.

Purpose of the Study:

  • To evaluate the association between the CHA2DS2-VASc-HSF score and CAD severity.
  • CAD severity was assessed using the SYNTAX score (SxS) in patients experiencing ST-segment elevation myocardial infarction (STEMI).

Main Methods:

  • 454 STEMI patients undergoing primary percutaneous coronary intervention were analyzed.
  • Patients were stratified into tertiles based on SYNTAX score (SxS): low (<14), intermediate (14-20), and high (≥21).

Main Results:

  • CHADS2, CHA2DS2-VASc, and CHA2DS2-VASc-HSF scores showed significant differences across SxS groups (p<0.001).
  • Multivariate analysis confirmed CHA2DS2-VASc-HSF score as an independent predictor of high SxS (OR 1.258, p=0.028), alongside age and ejection fraction.

Conclusions:

  • The CHA2DS2-VASc-HSF score is a novel predictor of atherosclerosis severity.
  • This score holds significant value for risk stratification in STEMI patients.
Abstract

Keywords:
CHADS2-VASc-HSF scoreSTEMIcoronary artery diseaseseverity

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