Related Experiment Video
Updated: Mar 22, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
The Link Between Adverse Childhood Experiences and Diabetes
Lindsay Huffhines1,2, Amy Noser1,2, Susana R Patton3,4
1University of Kansas, 1000 Sunnyside Avenue, Lawrence, KS, 66045, USA.
Childhood adversity, or adverse childhood experiences (ACEs), may increase diabetes risk. Some studies show a threshold effect, while others link greater abuse severity to higher diabetes risk, suggesting ACEs screening is important.
Area of Science:
- Public Health
- Epidemiology
- Psychology
Background:
- Adverse Childhood Experiences (ACEs) are linked to chronic adult diseases.
- Limited research exists on the impact of ACEs on diabetes risk.
- Understanding this link is crucial for preventative health strategies.
Purpose of the Study:
- To review the association between ACEs, trauma exposure, PTSD, and diabetes risk.
- To synthesize findings from existing research on ACEs and diabetes.
- To identify gaps in current knowledge.
Main Methods:
- Systematic review of 38 studies.
- Analysis of associations between ACEs, trauma, PTSD, and diabetes.
- Examination of dose-response and threshold-response relationships.
Main Results:
- Mixed results regarding abuse type and frequency.
- Some studies show a threshold-response, others a dose-response or severity-related risk.
- Chronic PTSD increased diabetes risk in veterans; trauma exposure predicted risk in community samples.
Conclusions:
- ACEs may be a significant predictor of diabetes risk and outcomes.
- Clinicians should consider screening for ACEs, abuse severity, and frequency.
- Further research is needed to clarify the complex relationship between ACEs and diabetes.
Related Concept Videos
Psychoneuroimmunology: Diabetes and Cancer
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

