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A combination of scGOS/lcFOS with Bifidobacterium breve M-16V protects suckling rats from rotavirus gastroenteritis

M Rigo-Adrover1,2, S Saldaña-Ruíz1,2, K van Limpt3

  • 1Department of Physiology, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n, 08028, Barcelona, Spain.

European Journal of Nutrition
|April 27, 2016
PubMed

Insights

A daily prebiotic and probiotic supplement effectively reduced rotavirus (RV) diarrhea in infant rats. Both interventions modulated immune responses and reduced viral shedding, offering a promising strategy for managing RV infections.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Immunology

Background:

  • Rotavirus (RV) is a primary cause of severe infant diarrhea.
  • Probiotics show potential against RV and other intestinal issues.
  • Prebiotic effects on RV infection require further investigation.

Purpose of the Study:

  • To evaluate the protective effects of a specific prebiotic mixture (scGOS/lcFOS 9:1), Bifidobacterium breve M-16V (probiotic), and their combination (synbiotic) in a rat model of RV infection.

Main Methods:

  • Suckling rats received oral gavage of prebiotic, probiotic, or synbiotic from day 3 to 21.
  • Rotavirus was administered on day 7.
  • Clinical parameters and immune responses were assessed.

Main Results:

  • Probiotic intervention decreased diarrhea incidence, severity, and duration.
  • Prebiotic and synbiotic interventions also improved clinical parameters and significantly reduced viral shedding.
  • All interventions modulated specific antibody responses in serum and intestinal washes.

Conclusions:

  • Daily supplementation with the scGOS/lcFOS 9:1 prebiotic mixture, Bifidobacterium breve M-16V, or their combination is highly effective in mitigating RV-induced diarrhea in a preclinical model.
Abstract

Keywords:
Bifidobacterium breveFOSGOSPrebioticProbioticRotavirusSynbiotic

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