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Updated: Mar 22, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Management of Patients with Sickle Cell Disease Using Transfusion Therapy: Guidelines and Complications

Stella T Chou1, Ross M Fasano2

  • 1Department of Pediatrics, Abramson Research Center, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 316D, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.

Hematology/Oncology Clinics of North America
|April 27, 2016
PubMed

Red blood cell (RBC) transfusion therapy is a key component of comprehensive management of patients with sickle cell disease (SCD) and has increased over time as a means of primary and secondary stroke prevention. RBC transfusions also prove to be lifesaving for many acute sickle cell-related complications. Although episodic and chronic transfusion therapy has significantly improved the morbidity and mortality of patients with SCD, transfusions are not without adverse effects. This review addresses RBC transfusion methods, evidence-based and/or expert panel-based consensus on indications for chronic and episodic transfusion indications, and strategies to prevent and manage transfusion-related complications.

Keywords:
AlloimmunizationIron overloadRed blood cell transfusionSickle cell disease

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