Relationship between mean platelet volume and central serous chorioretinopathy
Related Experiment Video
Updated: Mar 22, 2026
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
Ayhan Dursun1, Mustafa Ilker Toker2, Ayşe Vural Ozec2
1Department of Ophthalmology, School of Medicine, Cumhuriyet University, 58140, Sivas, Turkey. dursunayhan01@gmail.com.
Insights
Mean platelet volume (MPV) is significantly higher in patients with central serous chorioretinopathy (CSCR). Elevated MPV may serve as a valuable predictive marker for identifying individuals at risk of developing CSCR.
Area of Science:
- Ophthalmology
- Hematology
Background:
- Central serous chorioretinopathy (CSCR) is a condition affecting vision.
- Platelets play a role in various physiological and pathological processes.
Purpose of the Study:
- To investigate the association between mean platelet volume (MPV) and central serous chorioretinopathy (CSCR).
Main Methods:
- A comparative study involving 30 CSCR patients and 30 healthy controls.
- Ocular examinations and blood parameter analyses (including MPV and platelet count) were performed.
- Statistical analysis, including ROC curve analysis, was used to compare groups and determine predictive values.
Main Results:
- Patients with CSCR exhibited significantly higher MPV values (9.76 ± 1.36 fL) compared to controls (8.37 ± 0.72 fL) (p=0.004).
- No significant difference in platelet count was observed between the groups (p=0.253).
- An MPV cut-off value of >9.4 fL demonstrated 60.0% sensitivity and 93.3% specificity for predicting CSCR.
Conclusions:
- Mean platelet volume is significantly elevated in patients diagnosed with CSCR.
- MPV could potentially serve as a predictive biomarker for CSCR risk assessment.
Abstract:
The aim of this study was to investigate the mean platelet volume (MPV) of patients with central serous chorioretinopathy (CSCR). Thirty patients were included in the study. Thirty healthy volunteers were recruited as the control group. All patients and control subjects underwent complete ocular examination. Hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet count, and MPV of the participants were recorded. Data of patients with CSCR were compared with the control subjects. Patients with CSCR had significantly higher MPV values (9.76 ± 1.36 fL) compared with the control subjects (8.37 ± 0.72 fL) (p = 0.004). No significant difference was found in platelet counts between the CSCR group and the control group (259 ± 53.75 and 243 ± 52.11 K/Ul, p = 0.253). According to the receiver operator characteristics curve analysis, the optimal cut-off value of MPV to predict the CSCR was >9.4, with 60.0 % sensitivity and 93.3 % specificity. Our results demonstrated that the MPV values were significantly higher in patients with CSCR. MPV may be used as a predictive tool for identifying risk for CSCR.
More Related Videos
10:24Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
12:28Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
Published on: March 12, 2022