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Published on: August 12, 2020
Clinical practice of procalcitonin and hypersensitive c-reactive protein test in neonatal infection
Aimei Yao1, Jingyan Liu1, Jing Chang1
1Maternal and Child Health Hospital of Zhengzhou City, Zhengzhou, Henan, China.
Insights
Procalcitonin and high-sensitivity C-reactive protein tests aid in diagnosing neonatal infections. These biomarkers show significant differences across infection severity, proving valuable for early detection and treatment in newborns.
Area of Science:
- Neonatal Medicine
- Clinical Chemistry
- Infectious Diseases
Background:
- Neonatal infections pose significant health risks.
- Accurate and timely diagnosis is crucial for effective treatment.
- Biomarkers like procalcitonin and C-reactive protein are used to assess infection.
Purpose of the Study:
- To evaluate the clinical utility of procalcitonin and hypersensitive C-reactive protein (hs-CRP) tests in diagnosing neonatal infections.
- To compare biomarker levels across different infection severity groups in newborns.
Main Methods:
- A study involving 200 newborns with confirmed early infections was conducted.
- Participants were categorized into severe infection, local infection, non-infection, and healthy control groups.
- Serum levels of procalcitonin and hs-CRP were measured, with quantitative analysis before and after treatment in the severe infection group.
Main Results:
- Procalcitonin levels showed significant differences among all four groups (p<0.05).
- Hs-CRP positive rates differed significantly between the local infection group and healthy newborns, but not compared to the non-infection group (p>0.05).
- The severe infection group exhibited significant differences in both procalcitonin levels and hs-CRP positive rates compared to other groups.
Conclusions:
- Procalcitonin and hs-CRP are valuable tools for diagnosing early neonatal infections.
- These tests aid in differentiating infection severity and guiding treatment decisions in newborns.
- The findings support the clinical application of these biomarkers in neonatal infectious disease management.
Abstract:
To study the clinical practice of procalcitonin and hypersensitive c-reactive protein test in neonatal infection. Two hundred cases of our hospital treatment confirmed infection early newborn children were selected from February 2014 to March 2015. According to the condition, the children were divided into four groups as follows: severe infection group, local infection group, non-infection group and healthy newborns group. At the same time, the new healthy newborns were chosen as control group. The levels of serum procalcitonin and high-sensitivity C-reactive protein were detected in all children and the levels in severe infection group children before and after treatment were also quantitatively detected and the test results were analyzed. There was significant difference in procalcitonin among the four groups (pS<0.05). The positive rate of the high-sensitivity C-reactive protein in local infection group has no significant difference compared with the non-infection group (p>0.05). But there was significant difference between the local infection group and healthy newborn group. As for the severe infection group, both the levels of procalcitonin and positive rate of high-sensitivity C-reactive protein had significant difference compared with the other groups. The detection of procalcitonin and high-sensitivity C-reactive protein could contribute to the diagnose of the early infection neonatal children and has important values in diagnosis and treatment of infectious diseases in the newborns.
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