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Updated: Mar 22, 2026

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
Magnetic Resonance Imaging Abnormalities in Advanced Acute Bilirubin Encephalopathy Highlight
Jessica L Wisnowski1, Ashok Panigrahy2, Michael J Painter3
1Department of Pediatric Radiology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA.
Abstract:
A distinct pattern of acute restricted diffusion on magnetic resonance imaging localized to key regions within the dentato-thalamo-cortical pathway was observed early in a term newborn during advanced stages of acute bilirubin encephalopathy. These findings demonstrate that vulnerability to bilirubin toxicity extends across specific neuroanatomic tracts.

