Related Experiment Videos
[Neonatal hemangiomatosis with prolonged icterus]
J J Hendriks1, F H van de Staak, P M Vio
1Instituut voor Kindergeneeskunde, St. Radboudziekenhuis, K.U. Nijmegen.
Tijdschrift Voor Kindergeneeskunde
|February 1, 1989
Summary
Diffuse neonatal hemangiomatosis can cause cholestatic jaundice in infants. Prednisone therapy effectively normalized liver function, suggesting it is a preferred treatment over surgery.
Area of Science:
- Pediatric Gastroenterology
- Dermatology
- Neonatology
Background:
- Neonatal hemangiomas are common benign vascular tumors.
- Cholestatic jaundice in neonates requires prompt diagnosis and management.
- Diffuse neonatal hemangiomatosis is a rare, severe form of infantile hemangioma.
Observation:
- A six-week-old infant presented with multiple cutaneous hemangiomas and cholestatic jaundice.
- Exploratory laparotomy excluded biliary atresia (both extrahepatic and intrahepatic).
- Diagnosis was established as diffuse neonatal hemangiomatosis.
Findings:
- Prednisone therapy led to near-complete resolution of liver function abnormalities.
- The patient's cholestatic jaundice significantly improved with medical management.
- Surgical intervention was deemed inappropriate for this condition.
Implications:
- This case highlights the importance of considering diffuse neonatal hemangiomatosis in infants with unexplained cholestatic jaundice and hemangiomas.
- Systemic corticosteroid therapy (prednisone) is an effective treatment for liver dysfunction associated with this condition.
- Non-surgical management is recommended, challenging previous assumptions about surgical intervention for neonatal hemangiomatosis-related jaundice.